My must eats are as follows.
Dim Sum-Yank Sing
Crab and Oysters-Anchor Oyster Bar
Meat-House of Prime Rib
Sourdough-Boudin
Vietnamese fusion-Slanted Door
But there are so many choices and great places, I'm sure others will have great recommendations.
For wine tours, Sonoma is great. If you are a Cab fanatic, Napa has many more great Cab-centric wineries.