For a case you might look into the CM stacker (cooler master) it's a big SoB with 4 usb ports on the front another 4 or so on the back. Very large case, all metal too.
http://www.coolermaster.com/product.php?product_id=14
Speakers Logitech Z-5500 are very nice. I like logitech products.
http://reviews.logitech.com/7061/224...ws/reviews.htm
Monitors I'd go samsung with however large you need them to be I like the 16:10 widescreen.
Processor I use a AMD Phenom II X4 965 Black Edition, you could go with the 6 core version.
Probably get 8-12 gigs of RAM, that ones up to you
It depends on how much gaming and whatnot you are going to do but right now I run an Nvidia GeForce 9800 GT (one of my weaker pieces of hard ware) but it will still run every game that is out now on near MAX - MAX settings. So if you are looking to save some coin this is where I would do it.
I would get a solid state hard drive (the largest you can afford) and then 2 regular 1 TB or 2 TB hard drives for space. Again the SSD will only be your windows drive with all your programs, so don't feel the need to get an insanely large SSD but don't get a 50 gig either. Get whatever will hold everything you need + 25% or so for future expansion.