[shilala]

K's are, brother. I didn't mean to give the impression there was a k/9 category. My point was that middle relief and closers will yield far more k's than starters on a per inning average.

On the rest, we agree exactly. You can't go after all 20 categories on a regular basis or you end up mediocre in all of them.
The goal is to go .560. .500 will get you in the playoffs.
If I can regularly take 12 of 20, that's .600 ball. It's more than enough to win the season and get a shot at the playoffs. If I make it to the playoffs, it's a whole new season with a whole new cache of players either producing or not. Thats when a guy can make the changes he needs and watch daily matchups to get an edge.

Take a minute and break down what you're likely to get in each scenario. Reliever heavy, Closeer heavy, Starter heavy, Starter/middle relief heavy, etc.
I've found that it's best to go light on starters, normal on middle relief and heavy on closers. That's because I'll likely earn more than 5/10 categories per week, it's far easier to manage, and I can sit/swap out a starter who's blowing up.
I don't believe in a pitcher having a "bad game", for the most part. Seldom do they have one bad game, you can watch their stats and see something is wrong. I feel it's almost always injury. It doesn't take much of an injury to wreck mechanics because a guy will change his delivery to guard the injury, even if it's minor. Once he's gotten used to that different delivery, it takes hell for coaches to correct it, especially if they don't have enough accurate pre-analysis via film, slo-mo, etc. Most pitching coaches don't rely on computer-aided pitching analysis, they're old-school. That sets back and prolongs a guy's "bad game" syndrome for a good while till they retweak everything and get him back to where he started.
They'll push starting pitchers into the rotation forever. Middle relief and closers, they'll just sit them down and bring someone up, or whatever. They'll just keep his ass off the mound.
That's how I play it and a little of why. A guy can have just as much success with starting pitching/a little middle relief and no closers. I just feel it's more work and more risk. I've tried just about every combination and this one yields results for me.
The hitting side is tougher. I go with power-heavy, and those guys get hurt a lot. It makes things tough to fix if the injuries last and I don't have a comfortable margin.